Researchers from the Mattiroli group have found that the way DNA is packaged in cells can directly impact how fast DNA itself is copied during cell division. They discovered that DNA packaging sends signals through an unusual pathway, affecting the cell’s ability to divide and grow. This opens up new doors to study how the copying of the DNA and its packaging are linked. These findings, published in Molecular Cell, may help scientists to find therapies and medicines for diseases such as cancer in the future. Chromatin as a guide Every day, our cells divide. Each time they need to copy both their DNA and the structure in which the DNA is packed. This packaging, ...

Seawater electrolysis has long been seen as a promising pathway for sustainable hydrogen production but has faced significant limitations due to chloride ion (Cl⁻) corrosion, which can degrade a catalyst's performance. Now scientists from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences, along with their collaborators, have developed an efficient electrocatalyst called Co-N/S-HCS that demonstrates remarkable activity and stability in ...

LOS ANGELES — Researchers at City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the United States, ranked among the nation’s top 5 cancer centers by U.S. News & World Report and a national leader in providing cancer patients with best-in-class, integrated supportive care programs, now understand why taking an investigational white button mushroom supplement shows promise in slowing and even preventing prostate cancer from spreading among men who joined ...

November 12, 2024—(BRONX, NY)— Marina Konopleva, M.D., Ph.D., director of the Leukemia Program and co-director of the Blood Cancer Institute at the National Cancer Institute-designated Montefiore Einstein Comprehensive Cancer Center (MECCC), has joined forces with Break Through Cancer, a collaborative medical research foundation that supports teams of scientists as they advance treatments for some of the world’s deadliest cancers. Dr. Konopleva will play a pivotal role in the Eradicating Minimal Residual Disease (MRD) in Acute ...

Patients with a small cranial nerve tumor that can cause hearing loss, vertigo, imbalance and ringing in the ears have typically been watched rather than proactively treated, as the risks of early intervention were thought to outweigh the benefits. However, even those patients benefit significantly from non-invasive stereotactic radiosurgery, a multicenter, international study led by UVA Health physicians has found. Doctors typically treat larger forms of the tumors, called vestibular schwannomas, while taking a “watch and wait” approach ...

Washington, November 12, 2024—As student absenteeism reaches record highs in schools across the United States, new research finds that student absences are linked to lower teacher job satisfaction, raising concerns that this may exacerbate growing teacher shortages. The findings were published today in Educational Researcher, a peer-reviewed journal of the American Educational Research Association. The study, by Michael Gottfried and Colby Woods at the University of Pennsylvania, and Arya Ansari at The Ohio State University, is the first ...

(WASHINGTON, November 12, 2024) – Continuous enrollment in Medicaid was associated with a lower rate of a late-stage lymphoma diagnosis in children and adolescents/young adults (AYAs). However, fewer than half of Medicaid-insured patients in these age ranges were continuously enrolled before diagnosis, according to a study published today in Blood Advances. Lymphoma – which is divided into two types, Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) – is a cancer of the lymphatic system and ...

If knowledge is power, empowering the world with the art and science of negotiation offers even more far-reaching benefits – a more peaceful and prosperous world, according to the INSEAD Negotiation and Conflict Management Collaborative (NCMC). The Negotiation Course for the World (NCW) is a pioneering effort by the NCMC to make quality negotiation teaching materials and expertise accessible to all, and in so doing, democratise negotiation education. “It is an integral part of the NCMC’s mandate to bring scholars and practitioners together to collaborate on research and education on negotiation and conflict management,” said Roderick Swaab, Professor ...

By Benjamin Boettner   (BOSTON) — Ovarian cancer is more deadly than any other type of female reproductive organ cancer. It is estimated that in 2024, in the U.S. alone, more than 12,000 women will die from the disease because available therapies are not effective. To help overcome this striking deficit in women’s health, ARPA-H has selected a team at the Wyss Institute at Harvard University as an awardee of its Sprint for Women’s Health effort to develop “iNodes” – implantable lymphoid organs containing patients’ immune cells – as an entirely novel form of personalized immunotherapy to treat ovarian ...

In a recent study, researchers at the University of California, San Diego, have provided new insights into the central role of goblet cells—specialized cells that line the gut—in maintaining a healthy and balanced immune environment within the gastrointestinal (GI) tract. Led by Dr Fernanda Raya Tonetti, with Dr. Cristina Llorente directing the project and making significant contributions, the study underscores the critical roles of these cells, which act not only as a physical barrier but also ...

The Balkan Network of Science Journalists and the European Federation for Science Journalism are launching a new science journalism guide, this time in Romanian.  From the Field: A Science Journalist's Handbook is the result of a collective effort by more than 20 Romanian journalists and content creators who dedicated their time and expertise to build a 138-page document designed to help journalists navigate the complex world of science reporting. The guide was coordinated by science ...

SAN ANTONIO — November 12, 2024 — A Southwest Research Institute-led team combined compositional data of primitive bodies like Kuiper Belt objects, asteroids and comets with new solar data sets to develop a revised solar composition that potentially reconciles spectroscopy and helioseismology measurements for the first time. Helioseismology probes the Sun’s interior by analyzing the waves that travel through it, while spectroscopy reveals the surface composition based on the spectral signature produced by each chemical element.   A paper about this research, which ...

Background and Aims Necroptosis is critical for regulating intestinal epithelial cells (IECs). Butyric acid (BA), produced during intestinal microbial metabolism, protects the intestinal epithelial barrier. However, whether necroptosis occurs in IECs during liver cirrhosis and whether sodium butyrate (NaB) can regulate necroptosis have not yet been reported. In this study, we aimed to investigate whether IECs undergo necroptosis in cirrhosis and whether NaB can regulate necroptosis and the related regulatory mechanisms. Methods Serum levels of RIPK3, MLKL, and Zonulin, as well as fecal BA levels, were measured and correlated in 48 patients with liver cirrhosis ...

The story of Arctic greening has overlooked some main characters. At center stage are climate change and warming temperatures. Meanwhile, large grazing wildlife, such as caribou and muskoxen, also play a key role in the timing and abundance of Arctic plants, according to a study from the University of California, Davis. The study, published today in the journal PNAS Nexus, highlights the importance of large herbivores to the Arctic ecosystem, linking grazing with plant phenology and abundance in the Arctic tundra. Phenology is the study of the timing and cyclical patterns in nature, such as when birds migrate, or when a plant first sprouts or blooms. ...

A recent study led by researchers from the University of Illinois, including Dr. Hans Stein, confirms that a wide range of pork cuts, Italian hams, and sausages offer excellent protein quality. The study, published in JSFA Reports,1 utilized the Digestible Indispensable Amino Acid Score (DIAAS) method to measure protein quality, finding that all tested pork products, except one, achieved a DIAAS greater than 100, qualifying them as "excellent" protein sources for children, adolescents, and adults.  The researchers ...

CLEVELAND—The standard model for how galaxies formed in the early universe predicted that the James Webb Space Telescope (JWST) would see dim signals from small, primitive galaxies. But data are not confirming the popular hypothesis that invisible dark matter helped the earliest stars and galaxies clump together. Instead, the oldest galaxies are large and bright, in agreement with an alternate theory of gravity, according to new research from Case Western Reserve University published Tuesday November 12 in The Astrophysical Journal. The results challenge astronomers’ understanding of the early universe. “What the theory of dark matter predicted is not what we ...

WASHINGTON—Vitamin D supplements may lower blood pressure in older people with obesity and taking more than the Institutes of Medicine’s (IOM) recommended daily dose does not provide additional health benefits, according to new research published in the Journal of the Endocrine Society. The IOM recommends 600 International Units (IU) per day. Vitamin D deficiency is common worldwide and has been associated with heart disease, immunological diseases, infections and cancer. Studies have linked vitamin D deficiency to a higher risk of hypertension, but evidence for the beneficial effect of vitamin D supplementation on blood pressure outcomes ...

Up to two thirds of the world’s temperate rainforests could fall victim to climate change by the year 2100 according to a new study by researchers at the University of Leeds. In the first ever worldwide assessment of the impacts of global overheating on these rare ecosystems, scientists used maps of tree cover, forest condition, and climate data to assess how much of the world’s temperate rainforests have already been impacted by human activity and how climate change would push some regions to the brink. The results of their study which are published today (Tuesday 12 November) ...

The American Pediatric Society (APS) is pleased to announce ninety-eight new members. Founded in 1888, the APS is North America's first and most prestigious academic pediatric organization.  APS members are recognized child health leaders of extraordinary achievement who work together to shape the future of academic pediatrics. Current members nominate new members by recognizing individuals who have distinguished themselves as child health leaders, teachers, scholars, policymakers, and clinicians. “The Council of the APS is excited to welcome this large group of child health leaders ...

The World Health Organization describes obesity as an epidemic that disrupts metabolic equilibrium, characterized by an excess of adipose tissue and chronic inflammation. This state arises from various factors, including genetic predispositions and lifestyle choices like high caloric intake and physical inactivity​. Leptin, primarily produced by adipose tissue, regulates hunger by signaling satiety to the hypothalamus. However, in obesity, leptin's transport to the brain is often blocked, leading to leptin resistance. ...

A new study published in [Journal] highlights the critical role of lysosomes, cellular organelles responsible for waste disposal and recycling, in the development and progression of diabetes. Researchers from [Institution] have uncovered the complex interplay between lysosomal function and the pathogenesis of various diabetes types, including type 1, type 2, gestational diabetes, and cystic fibrosis-related diabetes. The study, titled “Lysosomal Stress in Pancreatic Endocrine Tissue in the Context of Diabetes Mellitus,” ...

Herbal medicine is difficult to produce on an industrial scale. A team of Kobe University bioengineers manipulated the cellular machinery in a species of yeast so that one such molecule can now be produced in a fermenter at unprecedented concentrations. The achievement also points the way to the microbial production of other plant-derived compounds. Herbal medicinal products offer many beneficial health effects, but they are often unsuitable for mass production. One example is artepillin C, which has antimicrobial, anti-inflammatory, antioxidant, and anticancer action, but is only available as a bee culture product. The Kobe University bioengineer ...

The cybersecurity refrain when encountering phishing emails invariably advises: “don’t click on that link” and “report that email” — but new research from Drexel University and Arizona State University has revealed a problematic reality: Most major companies do little to support reporting and few take action to shut down phishing sites disguised as their own after they have been reported. Recently presented at the International Symposium on Research in Attacks, Intrusions and ...

Decoding Deception: The Psychology of Combating Misinformation, a short film produced by Proceedings of the National Academy of Sciences with support from the Pulitzer Center, addresses one of the most pressing issues of our time: the quest to stem the swelling tide of misinformation. Decoding Deception explores potential remedies to this growing societal problem. While social media acts as an accelerant for the rampant spread of misinformation on climate change, public health, and politics, the rise of generative AI risks worsening the problem. Left unchecked, disinformation and misinformation can inflict lasting damage on people, institutions, and society ...

A study links herbivory to phenology in the Arctic. Phenology is the study of the timing of events in the natural world. In recent decades, researchers have investigated how climate change is shifting many natural events. Eric Post and colleagues wanted to understand how a different variable—the presence or absence of herbivores—affects the timing of spring plant growth, or green-up, in Greenland. In an experiment lasting nine years, the authors excluded musk oxen and caribou from some areas, then compared the timing of the spring green-up of 9 tundra plant species in the areas with and without herbivores. Of the plants that showed altered green-up between the conditions, about ...