BOSTON - Addiction is associated with social exclusion, loss of access to resources, and general disengagement from civic life. Now, a study recently published in the journal Psychology of Addictive Behaviors and led by David Eddie, PhD, of the Massachusetts General Hospital's Recovery Research Institute has found that the majority of Americans who have resolved an alcohol or other drug problem report achievements related to self-improvement, family engagement, and civic and economic participation since resolving their addiction. Additionally, it appears these achievements accumulate with time in addiction recovery. Incorporating data from the Recovery Research Institute's landmark 2017 National Recovery Study, which indicated ...

A new study by Stanford University biologists finds an explanation for the idea that physical characteristics such as skin pigmentation are "only skin deep." Using genetic modeling, the team has found that when two populations with distinct traits combine over generations, traits of individuals within the resulting "admixed" population come to reveal very little about individuals' ancestry. Their findings were published March 27 in a special edition of the American Journal of Physical Anthropology on race and racism. "When two founding groups first come together, a visible physical trait that differed between those founders initially carries information about the genetic ancestry of admixed individuals," says Jaehee Kim, a postdoctoral research fellow in biology at Stanford and first author ...

In the fight against cancers, activating mutations in the RAS family of genes stand in the way of finding viable treatment options. Now, scientists at the University of Missouri and Yale University have discovered that one of these mutations -- oncogenic RAS or RASV12 -- is also responsible for the regrowth of cancer cells following genotoxic therapy treatment, or drugs that cause damage to a cancer cell's DNA in order to eliminate it from the body. "Most of our knowledge of how cells respond to DNA damage is mainly derived from studies looking at the single cell level," said Yves Chabu, an assistant professor in the MU College of Arts and Science. "Therefore, we don't know much about how tumor cells respond to DNA damage in the broader ...

URBANA, Ill. ¬- If your day started with a cup of coffee, there's a good chance your morning brew came from Colombia. Home to some of the finest Arabica beans, the country is the world's third largest coffee producer. Climate change poses new challenges to coffee production in Colombia, as it does to agricultural production anywhere in the world, but a new University of Illinois study shows effects vary widely depending on where the coffee beans grow. "Colombia is a large country with a very distinct geography. The Andes Mountains cross the country from its southwest to northeast corner. Colombian coffee is currently growing in areas with different altitude levels, and climate impacts will likely be very different for low ...

Pregnancy can increase the risk of morbidity and mortality in women with cardiovascular disease; however, many cardiologists are not having pre-pregnancy contraception discussions with their patients of child-bearing age. There is a need to provide evidence-based guidance for contraceptive safety and effectiveness and pregnancy planning options for this high-risk patient group, according to a paper published in the Journal of the American College of Cardiology (JACC). This paper is one of a five-part JACC focus seminar series addressing a wide range of topics in the emerging cardio-obstetrics field. Prior research has found that 68% of females have had sex at least once by the time they were 17, ...

A recent study proposed a three-dimensional LotusMenu that can "bloom in the palm". With this menu, even if you are not Nezha, you can also control your own lotus. The research paper is titled: "LotusMenu: A 3D Menu using Wrist and Elbow Rotation Inspired by Chinese Traditional Symbol". It's published in SCIENCE CHINA Information Sciences recently, written by Associate Professor Lu Fei's human-computer interaction research team from Beijing University of Posts and Telecommunications. Based on the metaphor of the traditional lotus pattern, the researchers ...

The Bureau of Reclamation today released final technical reports supporting the Water Reliability in the West - 2021 SECURE Water Act Report. Reclamation's 2021 West-Wide Climate and Hydrology Assessment and seven individual basin reports provide detailed information on climate change impacts and adaptation strategies to increase water supply reliability in the West. A new 2021 SECURE Report Web Portal is also available to provide a user-friendly, web-based format for delivery of information in the reports. "Western water supply and delivery systems are affected by changing hydrologic conditions and competing demands," Deputy Commissioner Camille Calimlim Touton said. "These reports highlight Reclamation's effort to use ...

Humans have long explored three big scientific questions: evolution of the universe, evolution of Earth, and evolution of life. Geoscientists have embraced the mission of elucidating the evolution of Earth and life, which are preserved in the information-rich but incomplete geological record that spans more than 4.5 billion years of Earth history. Delving into Earth's deep-time history helps geoscientists decipher mechanisms and rates of Earth's evolution, unravel the rates and mechanisms of climate change, locate natural resources, and envision the future of Earth. Two common approaches, deductive reasoning ...

Researchers from North Carolina State University have developed an exosome-coated stent with a "smart-release" trigger that could both prevent reopened blood vessels from narrowing and deliver regenerative stem cell-derived therapy to blood-starved, or ischemic, tissue. Angioplasty - a procedure that opens blocked arteries - often involves placing a metal stent to reinforce arterial walls and prevent them from collapsing once the blockage is removed. However, the stent's placement usually causes some injury to the blood vessel wall, which stimulates smooth muscle cells to proliferate and migrate to the site in an attempt to repair the injury. The result is restenosis: a re-narrowing of the blood vessel previously opened by angioplasty. "The ...

ITHACA, N.Y. - The cost of harvesting solar energy has dropped so much in recent years that it's giving traditional energy sources a run for their money. However, the challenges of energy storage - which require the capacity to bank an intermittent and seasonally variable supply of solar energy - have kept the technology from being economically competitive. Cornell University researchers led by Lynden Archer, Dean and Professor of Engineering, have been exploring the use of low-cost materials to create rechargeable batteries that will make energy storage more ...

AMHERST, Mass. - A team of polymer science and engineering researchers at the University of Massachusetts Amherst has demonstrated for the first time that the positions of tiny, flat, solid objects integrated in nanometrically thin membranes - resembling those of biological cells - can be controlled by mechanically varying the elastic forces in the membrane itself. This research milestone is a significant step toward the goal of creating ultrathin flexible materials that self-organize and respond immediately to mechanical force. The team has discovered that rigid solid plates in biomimetic fluid membranes experience interactions ...

Mouse models of neurodevelopmental disorders possess unique, sex-specific metabolic dysfunctions, according to a new study in eNeuro. Understanding the unique metabolic effects of each disorder in both animal models and humans may lead to more personalized treatments and diagnostic methods. Any disorder affecting the brain also impacts the body. People with neurodevelopmental disorders -- including Down syndrome and autism spectrum disorders -- are at increased risk for developing diabetes, obesity, and hypertension. Yet the impact of these three disorders on metabolism has not been studied. Menzies et al. measured the resting energy metabolism of three neurodevelopmental disorder mouse models: Down syndrome, ...

A new report by AARP Pennsylvania and Drexel University's College of Nursing and Health Professions highlights how geographic, racial/ethnic and economic factors are combining to restrict access to health care services for many Pennsylvanians, creating disparities that have become more pronounced during the COVID-19 pandemic. "Disrupting Disparities in Pennsylvania: Retooling for Geographic, Racial and Ethnic Growth" shows that health inequities are most acute among those living in rural and low resourced areas of the state, and among underrepresented populations (particularly Black/African American and Latino), who lack access to health care, experience digital divide and face persistent ...

In an effort to save her beloved animals, Kathy Janson, a Maine Coon cat enthusiast reached out to a University of Cincinnati researcher to find a way to help her pets who were developing heart troubles. Maine Coon cats are known as great mousers, popular farm cats and, of course, for their enormous size. The New England breed is a really big cat and can weigh up to 19 pounds and grow up to 40 inches in length. Janson fell in love with these animals more than 25 years ago bringing them into her Cincinnati suburban home to become part of her family. "Maine ...

Researchers from the University of Minnesota Twin Cities College of Science and Engineering and Medical School have developed a unique head-mounted mini-microscope device that allows them to image complex brain functions of freely moving mice in real time over a period of more than 300 days. The device, known as the mini-MScope, offers an important new tool for studying how neural activity from multiple regions of the outer part of the brain, called the cortex, contribute to behavior, cognition and perception. The groundbreaking study provides new insight into fundamental research that could improve human brain conditions such as concussions, autism, Alzheimer's, and Parkinson's disease, as well as better understanding ...

A study at the University of Chicago Medicine found U.S. women experienced increased incidence of health-related socioeconomic risks (HRSRs), such as food insecurity and interpersonal violence, early in the COVID-19 pandemic. This was associated with "alarmingly high rates" of mental health problems, including depression and anxiety. The research was published April 5 in the Journal of Women's Health. Other studies have found evidence for higher rates of anxiety and depression and related issues, such as alcohol overuse, connected to the pandemic -- but this study is the first to link early pandemic-related changes in HRSRs to mental health effects ...

Researchers at the National Institute of Standards and Technology (NIST) and collaborators have demonstrated an atom-based sensor that can determine the direction of an incoming radio signal, another key part for a potential atomic communications system that could be smaller and work better in noisy environments than conventional technology. NIST researchers previously demonstrated that the same atom-based sensors can receive commonly used communications signals. The capability to measure a signal's "angle of arrival" helps ensure the accuracy of radar and wireless communications, ...

RIVERSIDE, Calif. -- A team led by a biomedical scientist at the University of California, Riverside, has developed a new RNA-sequencing method-- "Panoramic RNA Display by Overcoming RNA Modification Aborted Sequencing," or PANDORA-seq -- that can help discover numerous modified small RNAs that were previously undetectable. RNA plays a central role in decoding the genetic information in DNA to sustain an organism's life. It is generally known as the intermediate molecule used to synthesize proteins from DNA. Cells are full of RNA molecules in complex and diverse forms, two main types ...

Although stratospheric ozone protects us by filtering out the sun's ultraviolet radiation, tropospheric ozone is a harmful pollutant. A new study has shown that ozone in the lower layers of the atmosphere decreases crop yields in maize and changes the types of chemicals that are found inside the leaves. Ozone is formed when nitrous oxide, released from industries and tail pipes of cars, is broken down by sunlight and chemically reacts to form ozone. Researchers at the University of Illinois Urbana-Champaign have been studying the effects of ozone pollution on crops for over 20 years at a unique facility where crops can be grown under real-world farm ...

WINSTON-SALEM, N.C. - April 5, 2021 - According to the American Cancer Society, a noninvasive breast cancer called ductal carcinoma in situ (DCIS) accounts for approximately one of every four new breast cancer cases in the United States. If left untreated, DCIS has the potential to evolve into invasive cancer, so many patients choose to have breast-conserving surgery or mastectomy after a diagnosis. However, obtaining clear or negative margins -- no cancer cells in the outer edge of removed tissue -- is critical to mastectomy success as positive margins are associated with higher rates of recurrence. A new study from Wake Forest School of Medicine suggests removing ...

A new study published in Indoor Air provides design-based solutions on how to best use ultraviolet germicidal irradiation (UVGI) to disinfect occupied rooms without harming individuals. This research was conducted by Dorit Aviv, assistant professor of architecture and director of the Thermal Architecture Lab at the University of Pennsylvania Stuart Weitzman School of Design, Penn visiting scholar Miaomiao Hou, and Jovan Pantelic, an air quality expert at Katholieke Universiteit Leuven. Ultraviolet germicidal irradiation (UVGI) devices use short-wavelength ultraviolet ...

Palmer Amaranth is a high-impact agronomic weed species that has cost the United States agriculture industry billions of dollars since its discovery outside of its native range in the southwestern U.S. and northwestern Mexico. Over the last 20 years, it has moved further north, and now poses a major threat to corn, soybean, and cotton growers across the south and Midwest regions of the United States. It is not legal to sell any kind of seed in Minnesota if the seed lot contains Palmer Amaranth. The problem is this particular invasive species--which has shown potential to wipe out up to 91% of corn yields, 68% of soybean yields, and 54% of cotton yields-- is difficult to visibly distinguish from ...

Scientists create stable nanosheets containing boron and hydrogen atoms with potential applications in nanoelectronics and quantum information technology. What's thinner than thin? One answer is two-dimensional materials -- exotic materials of science with length and width but only one or two atoms in thickness. They offer the possibility of unprecedented boosts in device performance for electronic devices, solar cells, batteries and medical equipment. In collaboration with Northwestern University and the University of Florida, scientists from the U.S. Department of Energy's (DOE) Argonne National Laboratory report in Science ...

How do we become a complex, integrated multicellular organism from a single cell? While developmental biologists have long researched this fundamental question, Stanford University biologist and HHMI investigator Dominique Bergmann's recent work on the plant Arabidopsis thaliana has uncovered surprising answers. In a new study, published April 5 in Developmental Cell, led by Bergmann and postdoctoral scholar Camila Lopez-Anido, researchers used single-cell RNA sequencing technologies to track genetic activity in nearly 20,000 cells as they formed the surface and inner parts of an Arabidopsis leaf. Through this highly detailed technique, the researchers captured ...

PHILADELPHIA - A team led by scientists at the Perelman School of Medicine at the University of Pennsylvania has illuminated the functions of mysterious structures in cells called "nuclear speckles," showing that they can work in partnership with a key protein to enhance the activities of specific sets of genes. The discovery, which will be published on April 5 in Molecular Cell, is an advance in basic cell biology; the key protein it identifies as a working partner of speckles is best known as major tumor-suppressor protein, p53. This avenue of research may also lead to a better future understanding of cancers, and possibly better cancer treatments. "This study shows that nuclear speckles work as major regulators of gene expression, and suggests that ...