JACKSONVILLE, Fla. — A potentially powerful new approach to treating two lethal metastatic cancers — triple negative breast cancer and clear cell renal cell carcinoma, the most common form of kidney cancer — has been discovered by researchers at Mayo Clinic in Florida. In the online issue of Molecular Cancer Therapeutics, they report that two drugs, romidepsin and decitabine, work cooperatively to activate a potent tumor suppressor gene that is silenced in these cancers. Once the gene, secreted frizzled related protein one or sFRP1, went to work after the drugs were used, ...

NEW YORK (July 31, 2012) -- As a man's waistline grows, so can his experience with sexual dysfunction and frequent urination, say researchers at NewYork-Presbyterian Hospital/Weill Cornell Medical Center. The study, published in the August issue of the British Journal of Urology International (BJUI), is the first to comprehensively show that obesity in men affects not just their hearts and metabolism, but also their sexual and urinary health. "The findings demonstrate that obesity in men -- part of a growing global epidemic -- affects their well-being in profound ways," ...

A team of researchers from the Wildlife Conservation Society (WCS) and the National Research Council of Argentina recently fitted a South American sea bird called an imperial cormorant with a small camera, then watched stunned as it became "superbird" – diving 150 feet underwater in 40 seconds, feeding on the ocean floor for 80 seconds where it eventually caught a snakelike fish, before returning to the surface 40 seconds later. This is the first time researchers have been able to watch first-hand the amazing feeding techniques of these fascinating birds, which occur ...

DENVER, July 31, 2012 – Most people who have diabetes, high blood pressure, and high cholesterol have difficultly managing all three conditions; indeed, success is fleeting for those who do manage all three, according to a Kaiser Permanente Institute for Health Research study that appears online in the American Heart Association journal Circulation: Cardiovascular Quality and Outcomes. The study of close to 29,000 individuals enrolled at Kaiser Permanente Colorado and Denver Health found that only 30.3 percent at Kaiser Permanente and 16.2 percent of individuals at Denver ...

Cold Spring Harbor, NY – Research published Aug. 1 by scientists at Cold Spring Harbor Laboratory (CSHL) links gene mutations found in some patients with Meier-Gorlin syndrome (MGS) with specific cellular dysfunctions that are thought to give rise to a particularly extreme version of dwarfism, small brain size, and other manifestations of abnormal growth which generally characterize that rare condition. Although only 53 cases of Meier-Gorlin syndrome have been reported in the medical literature since the first patient was described in 1959, it is a malady whose mechanisms ...

The following highlights summarize research papers that have been recently published in Water Resources Research (WRR),Geophysical Research-Atmospheres (JGR-D), Journal of Geophysical Research-Space Physics (JGR-A), Journal of Geophysical Research-Biogeosciences (JGR-G), and Journal of Geophysical Research-Oceans (JGR-C). In this release: 1. The random walk of pollutants through river catchments 2. Atmospheric CO2 drove climate change during longest interglacial 3. Shear layers in solar winds affect Earth's magnetosphere 4. Dams impact carbon dynamics in U.S. rivers 5. ...

DETROIT -- Wayne State University School of Medicine researchers, working with colleagues in Canada, have found that one or more substances produced by a type of immune cell in people with multiple sclerosis (MS) may play a role in the disease's progression. The finding could lead to new targeted therapies for MS treatment. B cells, said Robert Lisak, M.D., professor of neurology at Wayne State and lead author of the study, are a subset of lymphocytes (a type of circulating white blood cell) that mature to become plasma cells and produce immunoglobulins, proteins that ...

More than 1.7 billion people worldwide may be classified as overweight and need appropriate medical or surgical treatment with the goal of sustainable weight loss. But for weight management programs to be effective, patients must complete them, states a study published in the Canadian Journal of Surgery (CJS) that analyzed drop-out rates and predictors of attrition within a publicly-funded adult weight management program. Researchers from the Department of Surgery at the University of Alberta and the Centre for the Advancement of Minimally Invasive Surgery at the Royal ...

Scientists at Western University have identified a new therapeutic target for advanced breast cancer which has shown tremendous promise in mouse models. The study led by Lynne-Marie Postovit of Western's Schulich School of Medicine & Dentistry looked at a protein called Nodal that is primarily found in embryonic or stem cells. Postovit discovered high levels of this protein in aggressive breast cancer tumors. Nodal was found to promote vascularization in the tumor, providing nutrients and oxygen to help it grow and spread. The research is published online in the journal ...

Because many physicians are unaware of nerve transfer surgery, some patients suffer long-term impairment from nerve injuries that could have been fixed. A study in the August issue of the Journal of the American Academy of Orthopaedic Surgeons (JAAOS) by Hospital for Special Surgery researchers aims to raise awareness of this type of surgery among health care providers. In recent years, great strides have been made in nerve transfer surgery, allowing many patients with a nerve injury in their upper extremity to have a remarkable recovery and improved functional outcomes. ...

As moms have always known, a good night's sleep is crucial to good health -- and now a new study led by a UCSF researcher shows that poor sleep can reduce the effectiveness of vaccines. The study is the first performed outside a sleep laboratory to show that sleep duration is directly tied to vaccine immune response, the authors said. The study, conducted while the UCSF researcher was a doctoral student at the University of Pittsburgh, will appear in the August issue of the journal "SLEEP." "With the emergence of our 24-hour lifestyle, longer working hours, and ...

Researchers at Case Western Reserve University School of Medicine have discovered a mutant form of the gene, Chk1, that when expressed in cancer cells, permanently stopped their proliferation and caused cell death without the addition of any chemotherapeutic drugs. This study illustrates an unprecedented finding, that artificially activating Chk1 alone is sufficient to kill cancer cells. "We have identified a new direction for cancer therapy and the new direction is leading us to a reduction in toxicity in cancer therapy, compared with chemotherapy or radiation therapy," ...

BOSTON (August 1, 2012) -- A comprehensive study using electronic dental records to profile the oral health status of adults with intellectual and developmental disabilities (I/DD) has concluded that access to specialized dental care alone is not sufficient to meet the community's substantial oral health needs. The findings, published as the cover article in the August issue of The Journal of the American Dental Association, provide a foundation for further investigation into the significant oral health needs of adults with I/DD and the development of preventive oral ...

MTR Global Venture Capital Group announced today that it has appointed Excel Trading Co., Limited's CEO Mr. Chuck M. Richardson to its Board of Directors team. Under Chuck's leadership, Excel Trading has sustained tremendous growth while considerably expanding its geographic reach. Since Chuck took the CEO position in 2008, Excel Trading has grown almost 450% from $85.5 Million to $348.75 Million, which is a great direction experience that Chuck is bringing to MTR Global as a part of his role in here. "We asked Mr. Richardson to join our Board of Directors because ...

Today EcoPlum, the green shopping rewards site, expands its online boutique with a unique collection of eco friendly products for the home by BottleHood. The new Home & Housewares section at EcoPlum launches with BottleHood's handcrafted glassware and wooden serving boards. These true American originals are made from reclaimed branded bottles and oak wine barrels. In August, customers purchasing BottleHood housewares at EcoPlum earn two EcoChipz rewards points for every dollar spent. BottleHood repurposes its glassware from wine, beer, liquor, soda and water bottles, ...

Inverkeithing, United Kingdom - (July 30, 2012) - Steel Buildings Design is part of the largest cold rolled steel building group in the United Kingdom. It is also the first ISO Quality Assured Steel Buildings supplier in the country. For more than 20 years, the company has been designing and building bespoke steel buildings for numerous clients. Today, Steel Buildings Design has expanded their products and services to include different types of buildings in their construction line up. Their building designs are suitable and can be adapted to almost any type of application. ...

As organizations struggle to perform against expectations and command attention in the age of immediacy, top thought leaders at Thruue Inc. are helping executives reinvent their corporate purpose/vision, and make transformational decisions for future relevancy and growth. Thruue Inc. is dedicated to the belief that only by enabling reflective thinking can big ideas emerge to drive action and evolve culture within high performing organizations. Internationally recognized author and strategist Daniel Forrester and seasoned consulting and service industry veteran Matt Lane ...

The dog dayz of this sizzling summer will be much cooler when high profile celebrities and their prized pooches receive HollyWOOF, Distinctive Assets' annual gift bag of the newest innovative dog products. Making sure Hollywood Hounds are found, Tagg - The Pet Tracker is an advanced pet tracking system equipped with GPS and wireless capabilities, enables owners to track where their pups are and be notified by text and email if they wander off beyond designated zones. For those D-List smells, itches and skin issues comes Farm Dog Naturals' new line of products, Relief ...

CDM Media extended an invitation to CIOs and IT executives today to speak at the upcoming CIO Manufacturing Summit, to be held Aug. 26-28, 2012, in Scottsdale, Ariz. The CIO Manufacturing Summit is the premier event for technology leaders and innovative thinkers, specifically CIOs, in the manufacturing industry. The summit's strategic agenda is designed to maximize efficiency and offer unique insight into present and future challenges facing CIOs in the industry. A few of this year's agenda session titles: - Securing the Smart Device-Do You Have a BYOC (Bring ...

Accurate Always, Inc today announced the launch of an educational website at http://www.voip-call-recording.com, which aims to simplify enterprise VoIP call recording by helping readers intelligently design and implement a comprehensive IP voice recording system from the start. As there are many proprietary IP-enabled PBX, gateways, media servers, SIP trunks and other ways to interface while recording IP voice, Accurate Always provides a map, with clear access to information and additional resources, which are helpful when determining how to best record VoIP calls with ...

The Lakeland Animal Shelter will host the 9th Annual Turtle Open to benefit the shelter on August 2, 2012, from 11 a.m. to 8 p.m. at Hawk's View Golf Club in Lake Geneva, Wis. Teams of four will have the opportunity to experience a great game of 18-hole scramble on Como Crossings at Hawk's View. Each team will enjoy golf, and carting around on Lake Geneva's only 5-star championship course. It is a par 72 course with 7,074 yards of challenging golf among beautiful woodlands. There will be a shotgun start at noon with a lunch buffet. Participants can also enjoy hole prize ...

San Francisco Giants outfielder Melky Cabrera has had the hot hand wearing Franklin batting gloves this season. The former Yankee and this year's All-Star MVP leads the Major Leagues with 139 hits, and would become the first Giants player to top the big leagues in hits since the immortal Willie Mays in 1960. Cabrera is hitting a blistering .353 as of Sunday's games with 10 home runs and 51 RBI. He is batting .361 in July. His average is second in the majors behind Andrew McCutchen of the Pirates at .368 Cabrera wears the Franklin model NEO CLASSIC gloves. Another ...

People often choose to file bankruptcy because they encounter a crisis in their lives, such as an unexpected job loss or medical bills, that destabilizes them financially. They seek bankruptcy protection in order to get a fresh start and regain their financial footing. Sometimes people need to consider bankruptcy more than one time in their lives and people should be aware of the restrictions the law places on filing for bankruptcymultiple times. Chapter 7 Bankruptcy Filing Limits Those who successfully filed Chapter 7 bankruptcy and received a debt discharge need ...

North Carolina residents who experience frequent pain in certain areas of the body may suffer from repetitive stress injury. The condition is referred to by a number of different names including repetitive strain injury, occupational overuse syndrome and cumulative trauma disorder. Individuals who suffer from severe RSI injuries may qualify for workers' compensation. RSI injuries are painful or uncomfortable feelings in the muscles, tendons, nerves or other soft tissues. They normally occur due to repetitive use of specific areas of the body. Arms, elbows and wrists ...

As people become more dependent on computers, they are storing more information digitally. What people might not realize is that they are creating digital assets that should be included in their estate plans. When people think of estate plans, they may only consider things like houses, money and other tangible personal property. However, some of the things people have online are just as important to them as assets traditionally included in estate plans, and people should take steps to ensure that they spell out their wishes for their digital assets in their estate plans. Making ...