This press release is available in German. As the "recycling plant" of the cell, the proteasome regulates vitally important functions. When it is inhibited, the cell chokes on its own waste. Cancer cells, in particular, are very sensitive because they need the proteasome for their uncontrolled growth. Biochemists at the Technische Universitaet Muenchen (TUM) have now identified the lead structure of a new class of drugs that attacks the proteasome in an unusual way. New medication could be developed on the basis of this previously unknown binding mechanism. The scientists ...

The National Trust has revealed the results from a new survey* which show that the vast majority (93 per cent) of people in Great Britain don't know the best time of year to enjoy eating British lamb. Only seven per cent of respondents correctly identified autumn as the time for tucking into one of Britain's favourites, with half (49 per cent) choosing spring as the best time to serve lamb - the time of year when most lambs are born. The research marks six months of the National Trust's mass on-line MyFarm experiment at its 1,200 acre organic farm at Wimpole in Cambridgeshire. ...

Super 8 Monroe North Carolina Hotel announces a special savings package for their hotel guest to enjoy. Guests who book their stay of 3 or more nights, from now through November 22, 2011 will receive a 20% discount off Best Available Rates (excluding taxes and incidentals). Stays must be completed by November 30, 2011. This offer cannot be combined with any other special rates and is subject to availability. As an additional bonus, now Wyndham Rewards members can earn DOUBLE miles or points with the stays you book until November 18th. All stays must be completed by ...

The latest invader of the Great Lakes—Hemimysis anomala, or more commonly the bloody red shrimp after its bright red spots—may become a new food source for fish, allaying concerns about how it will impact native fish populations. "Forecasting how an invader will affect the growth and production of a specific native fish species is very relevant to conservation groups and government agencies hoping to conserve those fish," says Biology graduate student Mike Yuille. Mr. Yuille is the lead author of a study that suggests for the first time that several native fish species ...

A remarkable first occurred recently at the Smithsonian's National Museum of Natural History when ornithologists Carla Dove and Storrs Olson used 700- to 1,100-year-old feathers from a long extinct species of Hawaiian ibis to help determine the bird's place in the ibis family tree. The feathers are the only known plumage of any of the prehistorically extinct birds that once inhabited the Hawaiian Islands. Discovered with a nearly complete skeleton, the feathers retained enough microscopic structure to allow the scientists to confirm the classification of the bird, known ...

"It feels like there's two of you inside – like there's another half of you, which is my anorexia, and then there's the real K, the real me, the logic part of me, and it's a constant battle between the two." - 36 year old study participant with anorexia nervosa. (Garrison, NY) People with anorexia nervosa struggle with questions about their real, or "authentic," self – whether their illness is separate from or integral to them – and this conflict has implications for compulsory treatment, concludes a study in the Hastings Center Report. The researchers also conclude that ...

Spook Spann, of Spook Nation TV, is selling 405 acres of hunting land in Grant, Iowa. Located in the heart of Iowa's prime buck land with a one acre working vineyard, this Iowa hunting property contains a great number of existing amenities and is sure to impress the most avid deer hunter. "I have personally harvested several great bucks off of this land, and I know that this will make an awesome farm for someone who is serious about hunting true world class bucks," asserts Spook Spann, professional hunter and manager of Spook Nation Farms. "When it comes ...

The question of how many polyhedral nanocrystals of silver can be packed into millimeter-sized supercrystals may not be burning on many lips but the answer holds importance for one of today's hottest new high-tech fields – plasmonics! Researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) may have opened the door to a simpler approach for the fabrication of plasmonic materials by inducing polyhedral-shaped silver nanocrystals to self-assemble into three-dimensional supercrystals of the highest possible density. Plasmonics ...

"My New Goalie has a first name, it's O-S-C-A-R..." "My new goalie has a first name, it's O-S-C-A-R..." Don't be surprised if you overhear an NHL GM singing this song to himself in a Pittsburgh hotel lobby in June 2012. Ok, it's pretty corny, so you probably won't actually hear anyone signing it, but come draft day, there will be a GM who will be feeling as happy as a kid with a hot dog. After all, he will have just selected a goalie named Oscar with his team's first round pick. Oscar Dansk is currently the highest ranked goalie in the upcoming ...

Concentrix, a global business service provider and wholly-owned subsidiary of SYNNEX Corporation, recently announced it has established a world-class contact center in Nicaragua. This new facility, located in the country's capital, has the capacity to house 60 service agents on its first phase and plans to increase to approximately 200 next year. The company's operations in Nicaragua will include a broad span of services in customer retention such as customer service and customer win-backs; in customer renewals such as licensing and contract renewals, extended warranty ...

NYU Langone Medical Center researchers have discovered the novel protective role dendritic cells play in the pancreas. The new study, published in the November issue of journal Gastroenterology, shows dendritic cells can safeguard the pancreas against acute pancreatitis, a sudden dangerous swelling and inflammation of the pancreas gland. "Our study findings demonstrate that an abundance of dendritic cells are needed in the pancreas for normal, healthy pancreatic function, especially when there are high levels of inflammation caused by acute pancreatitis," said senior ...

Having survived long centuries, political upheaval, and even bombings during World War II, Leonardo Da Vinci's masterpiece Last Supper now faces the risk of damage from air pollution due to its location in one of Western Europe's most polluted cities. In late 2009, the refectory of Santa Maria Delle Grazie Church, where the painting is located, installed a sophisticated heating, ventilation, and air conditioning system to protect the painting from the polluted air of Milan. To test the effectiveness of their pollution countermeasures, Italian officials called on Constantinos ...

GREENBELT, Md. -- The Visible Infrared Imager Radiometer Suite (VIIRS) onboard NASA's newest Earth-observing satellite, NPP, acquired its first measurements on Nov. 21, 2011. This high-resolution image is of a broad swath of Eastern North America from Canada's Hudson Bay past Florida to the northern coast of Venezuela. The VIIRS data were processed at the NOAA Satellite Operations Facility (NSOF) in Suitland, Md. VIIRS is one of five instruments onboard the National Polar-orbiting Operational Environmental Satellite System Preparatory Project (NPP) satellite that launched ...

Natural disasters are increasing around the world, leading many to construct emergency preparedness kits. Rocky Mountain Survival co-owners, Tim Shettlesworth and Dan Rivera, are raising the bar with their newly released disaster survival kit The custom designed pack undergoes rigorous field-testing to insure their efficacy. "We couldn't find survival kits that met all of our needs so we decided to design our own," said Shettlesworth. "I drew on past experience and extensive research for our disaster survival kit, and lived off the grid for a week using ...

NASA satellites have been watching hurricane Kenneth in the eastern Pacific, and today, Nov, 22, Kenneth became a late-season major hurricane. In fact, Kenneth sets a record for the latest season major hurricane in the eastern Pacific Ocean. A major hurricane is one that reaches category three status or greater on the Saffir-Simpson scale that measures hurricane strength. At 10 a.m. EST, Kenneth's maximum sustained winds were near 145 mph (230 kmh)! Kenneth's center was far away from land areas and about 750 miles (1210 km) south-southwest of the southern tip of Baja ...

"Ask yourself this question...as a boat owner, how much time do you spend cleaning your boat of bird droppings?" asks George Telheiro, CEO of Deck-Guard, LLC. "Wouldn't you rather be spending that time enjoying your boat? Absolutely! That's what Deck-Guard offers the pleasure boater." Masts, spreaders, canvas covers, radars, and railings on boats provide perfect perches for birds. Bird droppings can stain canvas covers and other surfaces and can be difficult to clean. Gulls, cormorants, pelicans and pigeons commonly use boats to land on. If neglected, ...

The German producer of special-purpose vehicles GSF Sonderfahrzeugbau has chosen a lithium ion battery based power solution from Clayton Power for their vehicles. This innovative technology helps them keep down the total payload and saves weight for other types of modern technology equipment. Modern special-purpose vehicles get heavier and heavier as they are filled with technology and specialized equipment. This increases the demand for ways to save weight in other areas - such as the power supply. Sales manager Mr. Eckhard Last explains how GSF has managed to ...

Researchers at Washington University School of Medicine in St. Louis have obtained new evidence that at least some persistent stuttering is caused by mutations in a gene governing not speech, but a metabolic pathway involved in recycling old cell parts. Beyond a simple association, the study provides the first evidence that mutations affecting cellular recycling centers called lysosomes actually play a role in causing some people to stutter. "This was extremely unexpected," says senior author Stuart A. Kornfeld, MD, the David C. and Betty Farrell Professor of Medicine. ...

Los Angeles, CA (November 22, 2011)) According to new research, wine promoters may want to spend more money on brochures and flyers and less money on wine tastings as they market to novice wine drinkers. A recent study published in Cornell Hospitality Quarterly (a SAGE journal) finds that without teaching about the background and process of wine production, new wine drinkers can be more easily influenced by advertising to make their purchases than their experienced counterparts. Authors Kathryn A. LaTour, Michael S. LaTour, and Andrew H. Feinstein wrote that while the ...

Expert Software Applications announced today the immediate availability of Mindomo Presenter - a radical new way to present Mind Maps online and offline. The strength of Mind Maps comes from their brain-friendly hierarchical structure. However, that strength is also a weakness when it comes to sharing a mind map. "A mind map has a single starting point and it has multiple ending points, it has no single path which will guide you trough every idea in a mind map. When creating a mind map there is no way to include a guidance to viewers which would make it easy to ...

Nomorerack (www.nomorerack.com) celebrates the largest shopping day of the year with a huge Black Friday through Cyber Monday Sale. The online discount shopping and daily deal site is taking Black Friday to new heights with a sale that lasts through the weekend and into Cyber Monday, starting at 12:00 AM EST November 25th through the 28th. Instead of the traditional 8 deals announced each day offering members up to 90% MSRP on today's hottest products, the weekend sale will unveil 90 deals every single day. This Black Friday sale will also feature surprise doorbuster ...

The sessions are aimed at informing British expatriates of ways to build and maximum their wealth, and to share vital information regarding new laws for UK citizens overseas. Invaluable advice and knowledge is to be offered by independent financial experts in several key destinations in Spain, Switzerland, Germany, Luxembourg, France, and Belgium. deVere Group Director, Mike Coady, says the seminars are part of the Group's global commitment to reaching clients wherever they are in the world. "With the worldwide economic situation as it is, it's more important ...

BINGHAMTON, NY – Helping at-risk high schoolers succeed in the classroom has always been difficult. Binghamton University Professor David Sloan Wilson thinks that he has a solution: design a school program that draws upon general theories of social behavior. Wilson, who has studied the evolution of social behavior throughout his career, recently had an opportunity to advise a new program for at-risk 9th and 10th graders in the upstate community of Binghamton, NY. Known as the Regents Academy, the program initiated in the Binghamton City School District was a huge success ...

PULLMAN, Wash. – Within the next few years, the number of planets discovered in orbits around distant stars will likely reach several thousand or more. But even as our list of these newly discovered "exoplanets" grows ever-longer, the search for life beyond our solar system will likely focus much more narrowly on the relatively few of these new worlds which exhibit the most Earth-like of conditions. For much of the scientific community, the search for alien life has long been dominated by the notion that our own planet serves as the best model of conditions best suited ...

ST. PAUL, Minn. – Studies have shown that people who are overweight in middle age are more likely to develop Alzheimer's disease decades later than people at normal weight, yet researchers have also found that people in the earliest stages of Alzheimer's disease are more likely to have a lower body mass index (BMI). A current study examines this relationship between Alzheimer's disease and BMI. The study, published in the November 22, 2011, print issue of Neurology®, the medical journal of the American Academy of Neurology, examined 506 people with advanced brain imaging ...