Tsukuba, Japan - Plants in the bean family (legumes) form nodules on their roots to take up nitrogen. Legumes will stop nodule production when nitrogen is plentiful (Figure 1), but precisely how nitrate presence controls nodule formation in these plants has been a mystery. Now, researchers from Japan have found that interactions between proteins and nitrate can induce and repress genes, controlling nodulation with potential applications in sustainable agriculture. In a study published in April in The Plant Cell, a research team from the University of Tsukuba has shown that the different DNA-binding properties between proteins that establish nodule development determine if genes involved in symbiosis that govern nodulation turn on or off and that ...

Two studies led by the Mental Health Unit of the Virgen del Rocio University Hospital and involving researchers from the US conclude that antipsychotic drugs could have a protective effect against SARS-CoV-2. For this reason, patients treated with these drugs have a lower risk of becoming infected or suffer a milder form of the disease if they do become infected. Thus, a first descriptive epidemiological study of a sample of 698 patients treated with antipsychotics at the Seville hospital revealed that antipsychotic drugs could provide protection against both infection and the tendency to clinical severity of Covid-19 infection. "These are very interesting findings that reflect a clinical reality where we see few patients ...

Since the beginning of the coronavirus pandemic, scientists and physicians worldwide undertook enormous efforts to understand the disease caused by the virus. In their latest collaborative study, researchers from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg and physicians from the University of Freiburg Medical Center unveil a novel feature of COVID-19 immunity, which could have implications for future therapies. The study points to the involvement of Interleukin 33, an important danger signal, when immune cells encounter Sars-CoV-2 for a ...

An international group of scientists led by the RIKEN Cluster for Pioneering Research have studied the chemical composition of 50 protoplanetary-disk forming regions in the Perseus Molecular Cloud, and found that despite being in the same cloud, the amounts of complex organic molecules they contain are quite different. Interestingly, the chemically rich young disks have similar compositions of organic molecules. These findings raise an important question: do solar-like systems share a common chemistry at birth? It was once believed that complex organic molecules were rare in the universe, and that this rarity ...

Imperial Brands scientists have utilised Toxys' ToxTracker suite of stem-cell based in-vitro assays, which provide mechanistic insight into the potential DNA damaging properties of chemicals, comparing vape e-liquid samples and their aerosols to combustible cigarette smoke. Imperial scientists are the first to publish results using the ToxTracker system for the assessment of vape e-liquids and aerosols, and it forms part of the company's continuing research into the tobacco harm reduction potential of Next Generation Products (NGPs) such as vapes. The assays help assess how product samples may impact cellular functioning across six reporter cell lines, picking up the tell-tale molecular signs of potential harm in the ...

Glass is ubiquitous, from high-tech products in the fields of optics, telecommunications, chemistry and medicine to everyday objects such as bottles and windows. However, shaping glass is mainly based on processes such as melting, grinding or etching. These processes are decades old, technologically demanding, energy-intensive and severely limited in terms of the shapes that can be realized. For the first time, a team led by Prof. Dr. Bastian E. Rapp from the Laboratory of Process Technology at the Department of Microsystems Engineering at the University of Freiburg, in collaboration with the Freiburg-based start-up Glassomer, has developed a process that makes it possible to form glass easily, quickly and in almost any shape using injection ...

The unpopular guests are already here. Hazel-, alder- and elm tree pollen sweep in over us during the early spring months, with birch pollen following in May. Then grass follows in June-July before mugwort pollen closes the season in late summer. All leading to more and more people suffering. Over fifty years, the proportion of young Danes who sneeze, rub itchy eyes or suffer a blocked nose because of pollen has grown from 7-8 per cent in the 1970s to 24 per cent today. And for asthma, the proportion has risen from 4 to 12 per cent during the same period. ...

Diet and the gut microbiome With the consumption of a single type of vegetable such as spinach, hundreds of chemical components enter our digestive tract. There, they are further metabolized by the gut microbiome, a unique collection of hundreds of microbial species. The gut microbiome thus plays a major role in determining how nutrition affects our health. "So far, however, the metabolic capabilities of many of these microorganisms in the microbiome are still unknown. That means we don't know what substances they feed on and how they process them," explains ...

Researchers at Lund University in Sweden have discovered that bird blood produces more heat in winter, when it is colder, than in autumn. The study is published in The FASEB Journal. The secret lies in the energy factories of cells, the mitochondria. Mammals have no mitochondria in their red blood cells, but birds do, and according to the research team from Lund and Glasgow this means that the blood can function as a central heating system when it is cold. "In winter, the mitochondria seem to prioritize producing more heat instead of more energy. The blood becomes a type of radiator that they can turn up when it gets colder", says Andreas Nord, researcher in evolutionary ecology at Lund University who led the study. Until ...

Ferroelectric materials are used in many devices, including memories, capacitors, actuators and sensors. These devices are commonly used in both consumer and industrial instruments, such as computers, medical ultrasound equipment and underwater sonars. Over time, ferroelectric materials are subjected to repeated mechanical and electrical loading, leading to a progressive decrease in their functionality, ultimately resulting in failure. This process is referred to as 'ferroelectric fatigue'. It is a main cause of the failure of a range of electronic devices, with discarded electronics a leading contributor to e-waste. Globally, tens of millions of tonnes of failed electronic devices go to landfill every year. Using advanced ...

During the acute phase of the COVID-19 pandemic, emergency department doctors, nurses and other frontline staff experienced unprecedented levels of stress and emotional exhaustion that included nightmares or insomnia, according to a UC San Francisco-led study of emergency departments across the country. The study, among the first to assess mental health effects of the pandemic at a geographically diverse sample of emergency rooms, found that nearly one-fifth of the ER staff were at elevated risk for post-traumatic stress disorder (PTSD). The study also reported that regular testing for COVID-19 helped to reduce stress among emergency personnel, particularly for those with previous positive antibody ...

COLUMBUS, Ohio - In some men, having traditional masculine characteristics such as competitiveness and adventurousness was linked to being better fathers to infants, a new study found. But the men in this study - highly educated and from dual-earner couples - combined those stereotypically masculine traits with the belief that they should be nurturing, highly involved fathers. The researchers were surprised that traits often seen as old-fashioned male stereotypes were linked to more positive parenting behaviors, said study lead author Sarah Schoppe-Sullivan, professor of psychology at The Ohio State University. It ...

An international research team led by Monash University has uncovered a new technique that could speed up recovery from bone replacements by altering the shape and nucleus of individual stem cells. The research collaboration involving Monash University, the Melbourne Centre for Nanofabrication, CSIRO, the Max Planck Institute for Medical Research and the Swiss Federal Institute of Technology in Lausanne, developed micropillar arrays using UV nanoimprint lithography that essentially 'trick' the cells to become bone. Nanoimprint lithography allows for the creation of microscale patterns with low cost, high ...

The concentration of the radioactive element radon is known to change in the ground before and after earthquakes. Previous studies have shown elevated radon levels in the atmosphere before the mainshock of a large inland earthquake due to foreshock activity and slow slip. But now, researchers from Tohoku University have revealed an anomaly in this phenomenon. Through the analysis of data before and after the 2018 Northern Osaka Earthquake, they discovered that the atmospheric radon concentration decreased. The results of their research were published online in Scientific Reports on April 2, 2021. "For the first time, we found a decrease in the atmospheric radon associated with seismic quiescence before the mainshock of ...

A team from the Department of Agronomy at the UCO has demonstrated, through field tests carried out during 8 agricultural seasons, that foliar feeding with fertilizer increases the concentration of zinc in wheat more than if it is applied to the soil Micronutrient deficiencies pose health problems for a third of the world's population. Worldwide, zinc deficits are more problematic in the rural areas of developing countries, where diets are largely limited to vegetable products grown in soils suffering from low nutrient availability. Biofortification, the process of bolstering the nutritional value of crops by increasing ...

Researchers at the Obesity Research Unit of the University of Helsinki have found that obesity clearly reduces mitochondrial gene expression in fat tissue, or adipose tissue. Mitochondria are important cellular powerplants which process all of our energy intake. If the pathways associated with breaking down nutrients are lazy, the changes can often have health-related consequences. A total of 49 pairs of identical twins discordant for body weight participated in the study conducted at the University of Helsinki: their body composition and metabolism were studied in detail, and biopsies from adipose and muscle tissue were collected. Multiple techniques for ...

WASHINGTON, April 9, 2021 -- For the millions of people worldwide who have sickle cell disease, there are only a few treatment options, which include risky bone marrow transplants, gene therapy or other treatments that address a subset of symptoms. Today, researchers will describe the discovery of a small molecule with the potential to address the root cause of sickle cell disease by boosting levels of fetal hemoglobin, a healthy form that adults normally do not make. The drug could be formulated into a convenient daily tablet. The researchers will present their results today at the spring meeting of the American Chemical Society (ACS). ACS Spring 2021 is being held online April 5-30. Live sessions will be hosted April 5-16, and on-demand and networking content will continue through ...

Osaka, Japan - Despite what some people think, bone is not merely a passive component of the body. The skeleton is structurally dynamic and responds to life's physical stresses with continual equilibration between bone mass loss and reformation. This ensures healing and remodeling in tune with the ebb and flow of calcium and phosphorus in the bloodstream. Now, researchers at Osaka university have identified a molecule--secretory leukocyte protease inhibitor (SLPI)--that helps mediate this critical balance, which could be used in the development of new treatments for bone diseases such as osteoporosis. Skeletal tissue changes are orchestrated ...

Exercise and a healthy diet in childhood leads to adults with bigger brains and lower levels of anxiety, according to new UC Riverside research in mice. Though diet and exercise are consistently recommended as ways to promote health, this study is the first to examine the long-lasting, combined effects of both factors when they are experienced early in life. "Any time you go to the doctor with concerns about your weight, almost without fail, they recommend you exercise and eat less," said study lead and UCR physiology doctoral student Marcell Cadney. "That's why it's surprising most studies only look at diet or exercise separately. In this study, we wanted to include both." The researchers determined that early-life exercise generally reduced anxious behaviors ...

Obesity is linked to heavier periods and may be caused by delayed repair of the womb lining, according to a study published in the Journal of Endocrinology. Using a combined approach, assessing both women and mice, the study suggests an association between higher body weight and greater menstrual blood loss that may result from increased inflammation in the womb lining, delaying its repair. Although the study did not examine whether weight loss or anti-inflammatory medications may be useful in treating women with obesity and heavy periods, this is a step towards developing more successful ...

Below the verdant surface and organic rich soil, life extends kilometers into Earth's deep rocky crust. The continental deep subsurface is likely one of the largest reservoirs of bacteria and archaea on Earth, many forming biofilms - like a microbial coating of the rock surface. This microbial population survives without light or oxygen and with minimal organic carbon sources, and can get energy by eating or respiring minerals. Distributed throughout the deep subsurface, these biofilms could represent 20-80% of the total bacterial and archaeal biomass ...

Early results show that a new combination drug therapy is safe and effective against advanced skin cancer in patients who were not able to have their tumors surgically removed. The drug combination is among the first, researchers say, to demonstrate the potential value of a live common cold virus, a coxsackievirus, to infect and kill cancer cells. The Phase I study, led by a researcher at NYU Langone Health and its Perlmutter Cancer Center, is also among the first to show how such oncolytic viruses can safely boost the action of widely used cancer therapies that help the body's immune defense system detect and kill cancer ...

An international team working at the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) used a unique X-ray instrument to learn new things about lithium-rich battery materials that have been the subject of much study for their potential to extend the range of electric vehicles and the operation of electronic devices. The researchers focused their investigations on a material called lithium manganese oxide (Li2MnO3), the extreme example of so-called "lithium-rich" materials, containing the largest amount of lithium possible within this family of materials. A recently developed tenet of the ...

A dementia diagnosis turns the world upside down, not only for the person affected but also for their relatives, as brain function gradually declines. Those affected lose their ability to plan, remember things or behave appropriately. At the same time, their motor skills also deteriorate. Ultimately, dementia patients are no longer able to handle daily life alone and need comprehensive care. In Switzerland alone, more than 150,000 people share this fate, and each year a further 30,000 new cases are diagnosed. To date, all attempts to find a drug to cure this disease ...

As demonstrated by multiple studies over the years, women who breastfeed have a lower risk for developing cardiovascular disease and diabetes when compared to those who don't or can't. However, the mechanisms by which these risks are reduced for lactating women are still not fully understood. Duke Appiah, Ph.D., an assistant professor of public health at the Texas Tech University Health Sciences Center and director of the university's master's program in public health, said the presence of excess fat, specifically visceral and pericardial fat could help explain this finding. Using that hypothesis, Appiah and a team of researchers recently completed a study titled, "The ...